Glyset, N-(b-Hydroxyethyl)-1-deoxynojirimycin,
Miglitol
CAS: 72432-03-2
Molecular Formula: C8H17NO5
Glyset, N-(b-Hydroxyethyl)-1-deoxynojirimycin, - Names and Identifiers
| Name | Miglitol |
| Synonyms | GLYSET Miglitol MIGLITOL Plumarol Diastabol GLYSET Plumarol Diastabol N-(B-HYDROXYETHYL)-1-DEOXYNOJIRIMYCIN N-(B-HYDROXYETHYL)-1-DEOXYNOJIRIMYCIN Glyset, N-(b-Hydroxyethyl)-1-deoxynojirimycin Glyset, N-(b-Hydroxyethyl)-1-deoxynojirimycin, 1,5-dideoxy-1,5-[(2-hydroxyethyl)imino]-D-glucitol 1,5-dideoxy-1,5-[(2-hydroxyethyl)imino]-D-glucitol 1-(2-hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol 1-(2-hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol (4R,5R)-1-(2-hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol (2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol |
| CAS | 72432-03-2 |
| EINECS | 276-661-6 |
| InChI | InChI=1/C8H17NO5/c10-2-1-9-3-6(12)8(14)7(13)5(9)4-11/h5-8,10-14H,1-4H2/t5?,6-,7?,8-/m1/s1 |
| InChIKey | IBAQFPQHRJAVAV-ULAWRXDQSA-N |
Glyset, N-(b-Hydroxyethyl)-1-deoxynojirimycin, - Physico-chemical Properties
| Molecular Formula | C8H17NO5 |
| Molar Mass | 207.22 |
| Density | 1.458±0.06 g/cm3(Predicted) |
| Melting Point | 114°C |
| Boling Point | 453.7±45.0 °C(Predicted) |
| Flash Point | 284.3°C |
| Water Solubility | Soluble |
| Solubility | DMSO 3 mg/mL;Water <1 mg/mL;Ethanol <1 mg/mL |
| Vapor Presure | 3.87E-10mmHg at 25°C |
| Appearance | White to light yellow crystal powder |
| Color | White |
| Merck | 14,6187 |
| pKa | 5.9(at 25℃) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month. |
| Refractive Index | 1.597 |
| MDL | MFCD00867240 |
| Use | For the treatment of diabetes |
Glyset, N-(b-Hydroxyethyl)-1-deoxynojirimycin, - Risk and Safety
| WGK Germany | 3 |
| RTECS | TN4350170 |
| HS Code | 29333990 |
Glyset, N-(b-Hydroxyethyl)-1-deoxynojirimycin, - Reference
| Reference Show more | 1. Hou, Xiaorong, et al. "Development of an immobilized liposome chromatography method for screening and characterizing α-glucosidase-binding compounds." Journal of Chromatography B 1148 (2020): 122097.https://doi.org/10.1016/j.jchromb.2020.122097 2. [IF=3.205] Xiaorong Hou et al."Development of an immobilized liposome chromatography method for screening and characterizing α-glucosidase-binding compounds."J Chromatogr B. 2020 Jul;1148:122097 |
Glyset, N-(b-Hydroxyethyl)-1-deoxynojirimycin, - Reference Information
| synthesis | at present, biosynthesis is mostly used to prepare miglitol. Miglitol biosynthesis according to the literature reported roughly two routes: one is the first by the wild or 1-deoxynojirimycin producing bacteria to produce fermentation, preparation of nojirimycin or 1-deoxynojirimycin, and then through chemical synthesis to obtain miglitol, which is the most original way; the second is to prepare N-substituted -1-deoxynojirimycin, a key intermediate of miglitol, by transforming gluconic acid bacteria, which is mainly prepared by the method of chemical synthesis-biological conversion-chemical synthesis. |
| dosage | for patients with type 2 diabetes mellitus. Blood samples were collected before and every 30 minutes after administration to 3 hours, and the mean blood glucose concentration time curve was plotted. Compared with the control group, 60~90 minutes after taking the drug, the blood glucose decreased most significantly, and there was no adverse reaction. Oral administration of 50 mg of miglitol has the same effect as oral administration of 300 mg of acarbose to reduce postprandial hyperglycemia and mean blood glucose concentration. The drug is not metabolized in the body, after oral administration of urine rapidly excreted in vitro. Clinical studies have shown that long-term oral administration of the drug has no significant effect on urinary system, cardiovascular system, respiratory system and blood parameters. Therefore, elderly patients, patients with liver function or mild renal impairment take this product does not need to adjust the dose. |
| interaction | ①. The combination of activated carbon intestinal adsorbent, containing amylase, trypsin and other digestive enzyme agent can be broken down sugar can reduce the hypoglycemic effect of this product, should avoid the use. This drug can reduce the curative effect of ranitidine. |
| biological activity | migritol (BAY-M-1099) is an oral antidiabetic drug. |
| Use | for the treatment of diabetes |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 20:49:11
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Multiple SpecificationsSpot supply
Product Name: Miglitol Visit Supplier Webpage Request for quotationCAS: 72432-03-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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